Major depressive disorder
Conditions
Interventions
Depression patients with early trauma:NO
Depression patients without early trauma:NO
Healthy control with early trauma:NO
Healthy control without early trauma:NO
Sponsors
The second xiangya hospital, Central South University, Changsha, Hunan, China
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients meeting DSM-4 diagnostic criteria of major depressive disorder; 2. HAMD scores more than 20 points(including); 3. Age from 18-45 years 4. Education years >=12years; 5. The Han nationality, right handness; 6. Informed consent.
Exclusion criteria
Exclusion criteria: 1. With psychotic symptoms; 2. With a history of alcohol and drug dependence; 3. With organic disease of brain and severe somatic disease; 4. With history of coma after brain trauma; 5. Woman with pregnancy or in lactation period; 6. With a history of seizures or with a family history of epilepsy; 7. Received thyroxine in 3 months before this study; 8. Receiving hormone for treatment; 9. Received drugs in 6 hours before MRI scan; 10. Exclusion of current infection, somatic trauma and autoimmune diseases; 11. With contraindications of MRI scan or with abnormal brain structure after MRI scan; 12. Shift workers, or with across time zones travel in last 6 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol;Brain structure;Brain function; | — |
Contacts
Public ContactLI LINGJIANG
Outcome results
None listed