Primary open angle glaucoma (including norma-tnesion and high-tension), ocular hypertension
Conditions
Interventions
Group E:MRI of brain and optic nerve/sheath complex, part of the patients undergo lumbar puncture for scientific reasons informed consent
Group A:MRI of brain and optic nerve/sheath complex, part of the patients undergo lumbar puncture for scientific reasons informed consent
Group B:MRI of brain and optic nerve/sheath complex, part of the patients undergo lumbar puncture for scientific reasons informed consent
Group C:MRI of brain and optic nerve/sheath complex, part of the patients undergo lumbar puncture for scientific reasons informed consent
Group D:MRI of brain and optic nerve/sheath complex, part of the patients undergo lumbar puncture for diagnostic or treatment reasons informed consent
Sponsors
Beijing Tongren Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. As for POAG, glaucomatous abnormalities of the opticnerve head, such as notches in the neuroretinal rim and localizedor segmental loss of the retinal nerve fiber layer, and glaucomatousvisual field defects as shown by computerized perimetry. The POAG patients was divided into NTG group in which all recorded IOP measurements (untreated and treated) were21 mmHg; 2. As forOHT, subjects were considered to have OHT if it was diagnosed by an ophthalmologist and they had a documented IOP higher than or equal to 24mmHg, normal-appearing optic nerve, and no visual field loss consistent with glaucoma. If a subject with OHT had a vertical cup-to-disc ratio of 0.3 or less, visual field analysis was not required for inclusion; 3. As for control subjects, Inclusion criteria were best-corrected Snellen visual acuity of 0.8 or better, intraocular pressure equal or less than 21 mmHg, normal optic disc appearance, absence of other ocular diseases, diabetes, and neurological disorders that may influence visual field results; 4. Subjects from the Neurological Department who are prepared to undergo LP for diagnostic or treatment reasons and the optic nerve/sheath complex have not pathological conditions.
Exclusion criteria
Exclusion criteria: 1. Any factors or disorders that could influence intracranial pressure, such as pseudotumor cerebri, intracranial tumors, oral medication (including drugs such as carbonic anhydrase inhibitors); 2. Any cranial surgery, traumatic brain injury, or lumbar puncture before inclusion in this study. 3. Without the informed consent signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral spinal fluid pressure;measurements of MRI;intraocular pressur; | — |
Countries
China
Contacts
Public ContactNingli Wang
Outcome results
None listed