Heart failure (HF)
Conditions
Interventions
Two groups:Echocardiography assesses LV asynchrony in both systole and diastole of Acute Heart Failure Decompensation in Patients for 4 years
2 groups:The study is a prospective, case-control design. It will employ advanced and sensitive echocardiographic technologies (ultrasound of the heart) to examine LV asynchrony in both systole (contr
1:In the cross-sectional study, 75 patients hospitalized for acute HF decompensation will be compared with another 75 patients with chronic stable HF to examine whether there are difference in the pre
1:This will be performed by using a number of validated parameters of asynchrony based on TDI and 3DE, and 75 normal controls will be selected to provide the reference normal cutoff values. Then, pati
1: Lastly, these patients will undergo exercise stress echocardiography at or before 1-month follow up to test the hypothesis whether dynamic LV asynchrony is a common condition in the group of HF pat
Sponsors
RGC funding
Eligibility
Sex/Gender
Male
Age
18 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1) Two groups of patients will be enrolled: (1) Patients who are admitted to acute medical ward for a diagnosis of acute HF (both first time presentation of HF or acute deterioration of chronic HF); (2) Patients with chronic stable HF who had no evidence of decompensation over the past 6 months; and 2) evidence of left ventricular (LV) systolic dysfunction with ejection fraction <50%; and, 3) normal QRS duration of <120ms.
Exclusion criteria
Exclusion criteria: 1) HF with ejection fraction >50%; 2) HF with wide QRS complex of >120ms; 3) Patients with fluid overload due to other conditions, such as renal failure or non-cardiogenic pulmonary oedema; 4) Patients with HF due to cardiac arrhythmia, thyrotoxicosis and other causes of high output HF; 5) Patients with atrial fibrillation that will preclude accurate analysis of systolic asynchrony, in particular 3DE; 6) Patients with poor image quality that preclude echocardiographic analysis; 7) Patients with disease with expected life expectancy 6 months, such as malignancies; 8) Patients who refuse to participate the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) LV ejection fraction; 2) LV end-systolic volume; 3) Asynchrony Index by TDI (Ts-SD); 4) Asynchrony Index by 3DE (Tmrv-16); 5) Difference in prevalence of dyssynchrony between 2 HF gps; 6) Change in prevalence of dyssynchrony within acute HF gp; 7) 6 minutes walk; 8) SF-36? Health Survey Questionnaire; 9) Neurohormonal levels; | — |
Contacts
Public ContactCheuk Man Yu
Outcome results
None listed