Severe Obstructive Sleep Apnea
Conditions
Interventions
Experimental group:Nutritional supplements
Sponsors
The Otolaryngology Department of Cheng Ching Hospital Chung Kang Branch
Eligibility
Sex/Gender
Male
Age
25 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age: 25-50; 2. Apnea-Hypopnea Index (AHI) >=30/h in multiple sleeping physical inspections; 3. Male; 4. BMI between 27 to 35.
Exclusion criteria
Exclusion criteria: craniofacial deformities, cancer, major liver and kidney diseases, stroke or heart disease history, taking anti-clotting medication drugs (Aspirin, coumadin, plavax), chronic obstructive pulmonary disease, narcolepsy, limb tic disorders at night time, central sleep apnea, or major mental illness (Schizophrenia, severe depression)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 8-isoprostane;RBC Glutathione Peroxidase;RBC superoxide dismutase;RBC catalase;malondialdehyde;Interleukin-6;Interleukin-8;Tumor necrosis factor alpha;Polysomnography / PSG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neck circumference;Waist circumference;Hip circumference;Systolic blood pressure;Diastolic blood pressure;Fasting blood sugar;Weight;Body Mass Index;Body fat percentage;Fasting insulin;Total cholesterol;Low density lipoprotein;High density lipoprotein;Triglyceride;high sensitivity C-reactive protein;Erythrocyte sedimentation rate;Hemoglobin; | — |
Countries
China
Contacts
Public ContactPo-Jen Liu
Outcome results
None listed