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The Clinical Trial of Ex-vivo Expansion and Translantation of Ocular Suface Epithelial Stem Cells and Oral Mucosa Epithelial Stem Therapies for Ocular Surface Reconstruction

The Clinical Trial of Ex-vivo Expansion and Translantation of Ocular Suface Epithelial Stem Cells and Oral Mucosa Epithelial Stem Therapies for Ocular Surface Reconstruction

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-OCB-15005973
Enrollment
Unknown
Registered
2014-10-16
Start date
2015-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ocular surface stem cells deficiency

Interventions

Experimental group 1:ex vivo expansion and transplantation of autologous autologous corneal epithelial stem cell
Experimental group 1:ex vivo expansion and transplantation of autologous autologous oral mucosal epithelial stem cell
Experimental group 3:ex vivo expansion and transplantation of autologous autologous conjunctival epithelial stem cell

Sponsors

Eye Institute of Xiamen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
7 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Partial limbal epithelial stem cell deficiency; 2. Total limbal epithelial stem cell deficiency; 3. Severe symblepharon; 4. Conjunctival sac stenosis.

Exclusion criteria

Exclusion criteria: 1. Marked ocular surface inflammatory activity; 2. Severe dry eye; 3. Progressive cicatricial disease; 4. Severe ocular surface squamous metaplasia; 5. Pregnant.

Design outcomes

Primary

MeasureTime frame
vision;Cornea Fluorescein Staining;slit lamp photography;—

Secondary

MeasureTime frame
ultrasound biomicroscopy (UBM);IOP(intraocular pressure);Schirmer test;break-up time;Optical Coherence Tomography (OCT);Impression cytology;—

Countries

China

Contacts

Public ContactWei Li
wei1018@xmu.edu.cn+86 0592-2183761

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026