chronic cheilitis
Conditions
Interventions
experimental group:tacrolimus 0.03% ointment is local uesd on lips
control group:acetonide 0.1% cream is local used on lips
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. history and the clinical manifestation of dry desquamation or eczema debaucjed of lips'; 2. aged 18~60 years; 3. the disease course is more than 2 months; 4. no abnormal with vital signs, routine physical examination and neurofunctional tests; 5. Volunteer to participate in and sign informed consent, good compliance with the medical advice, and be able to return on time.
Exclusion criteria
Exclusion criteria: 1. there is other disease characteristiced as erosive or other lesions on lips; 2. some severe dieases of mucosa; 3. Neuropsychiatric disorders, such as anxiety and depression, are being diagnosed and under the drug treatment; 4. Serious systemic disease or the abnormol value is above normal 30%; 5. local or system treatment with immunosuppressant in 2 weeks; 6. allergic to tacrolimus, acetonide, or other serious drug allergy history; 7. difficult to cooperate with doctor for the mental disorder; 8. pregnancy, intention of pregnancy, lactation,or use of systemic corticosteroids for the treatment of any diseases nearly; 9. addiction to smoking and alcohol; 10. participation in any other clinical trials in the 3 months before enrollment in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dryness (physical sign);desquamation (physical sign);rhagades(physical sign);swell(physical sign);plasma concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| dryness (symptom);desquamation(symptom);pain (symptom);itch (symptom);burning sensation (symptom); | — |
Countries
China
Contacts
Public ContactHongmei Zhou
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed