A randomized controlled trial of primary hypertension treated by diuretics combined with ARB compared to with CCB

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-17013419

Enrollment

Unknown

Registered

2017-11-16

Start date

2017-12-01

Completion date

Unknown

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary hypertention

Interventions

A:Erbesartan 150mg+ hydrochlorothiazide 12.5mg

B:lercanidipine 10mg+ hydrochlorothiazide 12.5mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 140mmHg and (or) diastolic blood pressure > 90mmHg; 2) 24 hours ambulatory blood pressure >130/80mmHg. All patients diagnosed as primary hypertention, including taking medicine and those not; 3. pacients not combined with severe heart, lung and kidney disease, and not allergy to ARB/CCB/diuretics.;Inclusion criteria: 1. Aged 140mmHg and (or) diastolic blood pressure > 90mmHg; 2) 24 hours ambulatory blood pressure >130/80mmHg. All patients diagnosed as primary hypertention, including taking medicine and those not; 3. pacients not combined with severe heart, lung and kidney disease, and not allergy to ARB/CCB/diuretics.

Exclusion criteria

Exclusion criteria: 1. Patients with hypertensive crisis and malignant hypertension; 2. Patient combined with severe heart and lung disease, tumor and other diseases is not suitable for this clinical trial; 3. allergy to ARB/CCB/diuretics ;Exclusion criteria: 1. Patients with hypertensive crisis and malignant hypertension; 2. Patient combined with severe heart and lung disease, tumor and other diseases is not suitable for this clinical trial; 3. allergy to ARB/CCB/diuretics

Design outcomes

Primary

Measure	Time frame
24h dynamic blood pressure;OBPM;;24h dynamic blood pressure;OBPM;	—

Secondary

Measure	Time frame
volume load;catecholamine;Renin activity (basis);electrolyte (potassium);renal function BUN;blood uric acid;CCr;;volume load;catecholamine;Renin activity (basis);electrolyte (potassium);renal function BUN;blood uric acid;CCr;	—

Countries

China

Contacts

Public ContactQiang She;Qiang She ;

Second Affiliated Hospital of Chongqing Medical University;Second Affiliated Hospital of Chongqing Medical University

qshe98@hotmail.com;qshe98@hotmail.com+86 13508393602;+86 13508393602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026