neonatal catheter-related infection
Conditions
Interventions
HA group:Inhalation of 7.5mg/ml ambroxol 2ml under endotracheal intubation, two times a day (with routine combined treatment and care)
NS group:Inhalation of 2ml normal saline under endotracheal intubation, two times a day (with routine treatment and care)
blank group:routine treatment and care only
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. The patient was admitted to NICU within 24 hours after birth and was intubated for the first time using a constant frequency ventilator; 2. Premature infants diagnosed with respiratory distress syndrome (NRDS) for the first time; 3. The family members shall sign the informed consent; 4. Choose the three generation cephalosporin antibiotics (because the pathogens are mainly gram negative bacteria).
Exclusion criteria
Exclusion criteria: 1. Sepsis, bronchopulmonary dysplasia, tracheoesophageal fistula, congenital heart disease, premature rupture of membranes, severe intracranial hemorrhage, and coagulation disorders; 2. Serious infection;] 3. Use antibiotics before the hospital; 4. The family refused to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of ventilator-associated pneumonia;Duration of mechnical ventilation;The positive rate of sputum culture;classification of bacteria; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of using antibiotics;Use of pulmonary surfactant;days of stay; | — |
Countries
China
Contacts
Public ContactXianhong Zhang
Children's Hospital of Chongqing Medical University
Outcome results
None listed