oral cancer
Conditions
Interventions
Group A:midazolam combined with hydromorphone
GroupB:propol combined with hydromorphone
GroupC:dexmedetomidine combined with hydromorphone
Sponsors
Stomatology Hospital, Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sixty patients with oral cancer were selected with elective surgery from June 2016 to June 2017, including male and female aged 18 to 80 years, weighing from 40 to 90 Kg, ASA grade I or II. They were performed radical surgeries, including primary enlargement resection, cervical lymphadenectomy, repair of oral and maxillofacial tissue defects by forearm flap, postoperative retention of tracheal intubation into ICU. ;Inclusion criteria: Sixty patients with oral cancer were selected with elective surgery from June 2016 to June 2017, including male and female aged 18 to 80 years, weighing from 40 to 90 Kg, ASA grade I or II. They were performed radical surgeries, including primary enlargement resection, cervical lymphadenectomy, repair of oral and maxillofacial tissue defects by forearm flap, postoperative retention of tracheal intubation into ICU. ;Inclusion criteria: Sixty patients with oral cancer were selected with elective surgery from June 2016 to June 2017, including male and female aged 18 to 80 years, weighing from 40 to 90 Kg, ASA grade I or II. They were performed radical surgeries, including primary enlargement resection, cervical lymphadenectomy, repair of oral and maxillofacial tissue defects by forearm flap, postoperative retention of tracheal intubation into ICU. ;Inclusion criteria: Sixty patients with oral cancer were selected with elective surgery from June 2016 to June 2017, including male and female aged 18 to 80 years, weighing from 40 to 90 Kg, ASA grade I or II. They were performed radical surgeries, including primary enlargement resection, cervical lymphadenectomy, repair of oral and maxillofacial tissue defects by forearm flap, postoperative retention of tracheal intubation into ICU. ;Inclusion criteria: Sixty patients with oral cancer were selected with elective surgery from June 2016 to June 2017, including male and female aged 18 to 80 years, weighing from 40 to 90 Kg, ASA grade I or II. They were performed radical surgeries, including primary enlargement resection, cervical lymphadenectomy, repair of oral and maxillofacial tissue defects by forearm flap, postoperative retention of tracheal intubation into ICU.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal nervous system or disease such as severe central nervous system or tumors or who have undergone intracranial surger; 2. patients with severe diabetes, high blood sugar, and overweight; 3. pregnant and lactating female patients; 4. patients with severe liver and kidney dysfunction; 5. patients with long term use of Benzodiazepines and morphine-derivative drugs; 6. patients with allergies to dexmedetomidine and propofol. ;Exclusion criteria: 1. Patients with abnormal nervous system or disease such as severe central nervous system or tumors or who have undergone intracranial surger; 2. patients with severe diabetes, high blood sugar, and overweight; 3. pregnant and lactating female patients; 4. patients with severe liver and kidney dysfunction; 5. patients with long term use of Benzodiazepines and morphine-derivative drugs; 6. patients with allergies to dexmedetomidine and propofol. ;Exclusion criteria: 1. Patients with abnormal nervous system or disease such as severe central nervous system or tumors or who have undergone intracranial surger; 2. patients with severe diabetes, high blood sugar, and overweight; 3. pregnant and lactating female patients; 4. patients with severe liver and kidney dysfunction; 5. patients with long term use of Benzodiazepines and morphine-derivative drugs; 6. patients with allergies to dexmedetomidine and propofol. ;Exclusion criteria: 1. Patients with abnormal nervous system or disease such as severe central nervous system or tumors or who have undergone intracranial surger; 2. patients with severe diabetes, high blood sugar, and overweight; 3. pregnant and lactating female patients; 4. patients with severe liver and kidney dysfunction; 5. patients with long term use of Benzodiazepines and morphine-derivative drugs; 6. patients with allergies to dexmedetomidine and propofol. ;Exclusion criteria: 1. Patients with abnormal nervous system or disease such as severe central nervous system or tumors or who have undergone intracranial surger; 2. patients with severe diabetes, high blood sugar, and overweight; 3. pregnant and lactating female patients; 4. patients with severe liver and kidney dysfunction; 5. patients with long term use of Benzodiazepines and morphine-derivative drugs; 6. patients with allergies to dexmedetomidine and propofol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RamsayScore;TNF- a;IL - 6; | — |
Countries
China
Contacts
Public ContactWang Li;Wang Li;Wang Li;Wang Li;Wang Li ;;;;
Stomatology Hospital, Wuhan University;Stomatology Hospital, Wuhan University;Stomatology Hospital, Wuhan University;Stomatology Hospital, Wuhan University;Stomatology Hospital, Wuhan University
Outcome results
None listed