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A prospective, rater-blinded and self-controlled pilot study of the treatment of infantile hemangioma with oral propranolol versus combined with 0.5% topical timolol cream

A prospective, rater-blinded and self-controlled pilot study of the treatment of infantile hemangioma with oral propranolol versus combined with 0.5% topical timolol cream

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-17013197
Enrollment
Unknown
Registered
2017-11-01
Start date
2016-01-01
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infantile hemangioma

Interventions

oral propranolol group:oral propranolol alone
combination group:combination of oral propranolol and topical timolol

Sponsors

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School Of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients of infantile hemangioma that were diagnosed according to the criteria of the International Society for the Study of Vascular Anomalies, younger than 1 year old; 2. no previous treatment with other medications; and 3. agreement to the participation and signed the informed consent provided by patients guardians. ;Inclusion criteria: 1. Patients of infantile hemangioma that were diagnosed according to the criteria of the International Society for the Study of Vascular Anomalies, younger than 1 year old; 2. no previous treatment with other medications; and 3. agreement to the participation and signed the informed consent provided by patients guardians. ;Inclusion criteria: 1. Patients of infantile hemangioma that were diagnosed according to the criteria of the International Society for the Study of Vascular Anomalies, younger than 1 year old; 2. no previous treatment with other medications; and 3. agreement to the participation and signed the informed consent provided by patients guardians. ;Inclusion criteria: 1. Patients of infantile hemangioma that were diagnosed according to the criteria of the International Society for the Study of Vascular Anomalies, younger than 1 year old; 2. no previous treatment with other medications; and 3. agreement to the participation and signed the informed consent provided by patients guardians. ;Inclusion criteria: 1. Patients of infantile hemangioma that were diagnosed according to the criteria of the International Society for the Study of Vascular Anomalies, younger than 1 year old; 2. no previous treatment with other medications; and 3. agreement to the participation and signed the informed consent provided by patients guardians.

Exclusion criteria

Exclusion criteria: 1. patients who had a history of allergies to ß-adrenergic receptor antagonist and 2. had any contraindications or complications (e.g. ulceration, local infection, bronchial asthma); 3. congenital hemangioma.;Exclusion criteria: 1. patients who had a history of allergies to ß-adrenergic receptor antagonist and 2. had any contraindications or complications (e.g. ulceration, local infection, bronchial asthma); 3. congenital hemangioma.;Exclusion criteria: 1. patients who had a history of allergies to ß-adrenergic receptor antagonist and 2. had any contraindications or complications (e.g. ulceration, local infection, bronchial asthma); 3. congenital hemangioma.;Exclusion criteria: 1. patients who had a history of allergies to ß-adrenergic receptor antagonist and 2. had any contraindications or complications (e.g. ulceration, local infection, bronchial asthma); 3. congenital hemangioma.;Exclusion criteria: 1. patients who had a history of allergies to ß-adrenergic receptor antagonist and 2. had any contraindications or complications (e.g. ulceration, local infection, bronchial asthma); 3. congenital hemangioma.

Design outcomes

Primary

MeasureTime frame
VAS;Spectral Doppler Ultrasound;

Countries

China

Contacts

Public ContactLi Wei;Li Wei;Li Wei;Li Wei;Li Wei ;;;;

Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine;Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine;Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine;Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine;Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine

liweiboshi@163.com;liweiboshi@163.com;liweiboshi@163.com;liweiboshi@163.com;liweiboshi@163.com+96 13916936121;+96 13916936121;+96 13916936121;+96 13916936121;+96 13916936121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026