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The effects and safety of topiramate or metformin on obesity induced by antipsychotics in patients with mental disorders: a randomized clinical trial

A control study of effects of topiramate on obesity induced by antipsychotics

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-17013122
Enrollment
Unknown
Registered
2017-10-26
Start date
2012-09-03
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity caused by antipsychotics

Interventions

Sponsors

Huaian 3rd People's Hospital, Jiangsu Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Aged 15 to 55 years; 2. Meet the diagnosis of schizophrenia or affective disorder in the 3rd edition of Chinese psychiatric disorders classification and diagnostic criteria; 3. Met for the criteria of obesity induced by antipsychotics. Obesity was based on body mass index(BMI)>25kg/m2, 23kg/m225kg/m2 after taking antipsychotics; 4. Signed informed consent for this study. ;Inclusion criteria: 1. Aged 15 to 55 years; 2. Meet the diagnosis of schizophrenia or affective disorder in the 3rd edition of Chinese psychiatric disorders classification and diagnostic criteria; 3. Met for the criteria of obesity induced by antipsychotics. Obesity was based on body mass index(BMI)>25kg/m2, 23kg/m225kg/m2 after taking antipsychotics; 4. Signed informed consent for this study. ;Inclusion criteria: 1. Aged 15 to 55 years; 2. Meet the diagnosis of schizophrenia or affective disorder in the 3rd edition of Chinese psychiatric disorders classification and diagnostic criteria; 3. Met for the criteria of obesity induced by antipsychotics. Obesity was based on body mass index(BMI)>25kg/m2, 23kg/m225kg/m2 after taking antipsychotics; 4. Signed informed consent for this study. ;Inclusion criteria: 1. Aged 15 to 55 years; 2. Meet the diagnosis of schizophrenia or affective disorder in the 3rd edition of Chinese psychiatric disorders classification and diagnostic criteria; 3. Met for the criteria of obesity induced by antipsychotics. Obesity was based on body mass index(BMI)>25kg/m2, 23kg/m225kg/m2 after taking antipsychotics; 4. Signed informed consent for this study. ;Inclusion criteria: 1. Aged 15 to 55 years; 2. Meet the diagnosis of schizophrenia or affective disorder in the 3rd edition of Chinese psychiatric disorders classification and diagnostic criteria; 3. Met for the criteria of obesity induced by antipsychotics. Obesity was based on body mass index(BMI)>25kg/m2, 23kg/m225kg/m2 after taking antipsychotics; 4. Signed informed consent for this study.

Exclusion criteria

Exclusion criteria: 1. Mental disorder caused by brain organic and/or somatic diseases; 2. Mental disorder induced by substance abuse; 3. There is a history of obesity, diabetes mellitus and endocrine disease before suffering from mental diseases; 4. Other interventions were being involved.;Exclusion criteria: 1. Mental disorder caused by brain organic and/or somatic diseases; 2. Mental disorder induced by substance abuse; 3. There is a history of obesity, diabetes mellitus and endocrine disease before suffering from mental diseases; 4. Other interventions were being involved.;Exclusion criteria: 1. Mental disorder caused by brain organic and/or somatic diseases; 2. Mental disorder induced by substance abuse; 3. There is a history of obesity, diabetes mellitus and endocrine disease before suffering from mental diseases; 4. Other interventions were being involved.;Exclusion criteria: 1. Mental disorder caused by brain organic and/or somatic diseases; 2. Mental disorder induced by substance abuse; 3. There is a history of obesity, diabetes mellitus and endocrine disease before suffering from mental diseases; 4. Other interventions were being involved.;Exclusion criteria: 1. Mental disorder caused by brain organic and/or somatic diseases; 2. Mental disorder induced by substance abuse; 3. There is a history of obesity, diabetes mellitus and endocrine disease before suffering from mental diseases; 4. Other interventions were being involved.

Design outcomes

Primary

MeasureTime frame
Body weight;Height;Waist circumference;Hip circumference;

Secondary

MeasureTime frame
Liver function;Blood routine;Electrocardiogram;Fasting blood-glucose;

Countries

China

Contacts

Public ContactCongjie Wang;Congjie Wang;Congjie Wang;Congjie Wang;Congjie Wang ;;;;

Huaian 3rd People's Hospital, Jiangsu Province;Huaian 3rd People's Hospital, Jiangsu Province;Huaian 3rd People's Hospital, Jiangsu Province;Huaian 3rd People's Hospital, Jiangsu Province;Huaian 3rd People's Hospital, Jiangsu Province

jakew19877@163.com;jakew19877@163.com;jakew19877@163.com;jakew19877@163.com;jakew19877@163.com+86 13852366102;+86 13852366102;+86 13852366102;+86 13852366102;+86 13852366102

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 17, 2026