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Effects of folic acid in preventing the dysfunction of native arteriovenous fistulas in uremia patients: a single-center, single-blind, randomized, Placebo-controlled trial

Role of endothelial glycocalyx in predicting the dysfunction of native arteriovenous fistulas (AVF) in uremia patients and the effects of folic acid in treatment of dysfunction of AVF

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-17013111
Enrollment
Unknown
Registered
2017-10-25
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dialysis access

Interventions

Treatment group:folic acid, 10mg/tid
Control group:placebo

Sponsors

Shandong Provincial Qianfoshan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Male or female =18 years old; 2. Patients diagnosed with uremia (GFR<15ml/(ml/min/1.73m2)); 3. Accepting the hemodialysis; 4. Accepting end-to-side in upper limb arteriovenous fistula for dialysis access; 5. Signed the informed consent form prior to the study participation.;Inclusion criteria: 1. Male or female =18 years old; 2. Patients diagnosed with uremia (GFR<15ml/(ml/min/1.73m2)); 3. Accepting the hemodialysis; 4. Accepting end-to-side in upper limb arteriovenous fistula for dialysis access; 5. Signed the informed consent form prior to the study participation.;Inclusion criteria: 1. Male or female =18 years old; 2. Patients diagnosed with uremia (GFR<15ml/(ml/min/1.73m2)); 3. Accepting the hemodialysis; 4. Accepting end-to-side in upper limb arteriovenous fistula for dialysis access; 5. Signed the informed consent form prior to the study participation.;Inclusion criteria: 1. Male or female =18 years old; 2. Patients diagnosed with uremia (GFR<15ml/(ml/min/1.73m2)); 3. Accepting the hemodialysis; 4. Accepting end-to-side in upper limb arteriovenous fistula for dialysis access; 5. Signed the informed consent form prior to the study participation.;Inclusion criteria: 1. Male or female =18 years old; 2. Patients diagnosed with uremia (GFR<15ml/(ml/min/1.73m2)); 3. Accepting the hemodialysis; 4. Accepting end-to-side in upper limb arteriovenous fistula for dialysis access; 5. Signed the informed consent form prior to the study participation.

Exclusion criteria

Exclusion criteria: Patients with malignant disease; Active autoimmune diseases; Acute or chronic infection disease, such as tuberculosis; Severe cardiovascular, brain, liver, or hematopoietic system disease; Serious gastrointestinal disease which affect drug absorption, such as active ulcer, chronic diarrhea, post gastrointestinal surgery etc. Women in pregnancy or lactation; Can not be partners, such as the mentally ill; With alcohol or drug abuse; Enrolled in other trials; Any other conditions that researchers think not suitable for this experiment.;Exclusion criteria: Patients with malignant disease; Active autoimmune diseases; Acute or chronic infection disease, such as tuberculosis; Severe cardiovascular, brain, liver, or hematopoietic system disease; Serious gastrointestinal disease which affect drug absorption, such as active ulcer, chronic diarrhea, post gastrointestinal surgery etc. Women in pregnancy or lactation; Can not be partners, such as the mentally ill; With alcohol or drug abuse; Enrolled in other trials; Any other conditions that researchers think not suitable for this experiment.;Exclusion criteria: Patients with malignant disease; Active autoimmune diseases; Acute or chronic infection disease, such as tuberculosis; Severe cardiovascular, brain, liver, or hematopoietic system disease; Serious gastrointestinal disease which affect drug absorption, such as active ulcer, chronic diarrhea, post gastrointestinal surgery etc. Women in pregnancy or lactation; Can not be partners, such as the mentally ill; With alcohol or drug abuse; Enrolled in other trials; Any other conditions that researchers think not suitable for this experiment.;Exclusion criteria: Patients with malignant disease; Active autoimmune diseases; Acute or chronic infection disease, such as tuberculosis; Severe cardiovascular, brain, liver, or hematopoietic system disease; Serious gastrointestinal disease which affect drug absorption, such as active ulcer, chronic diarrhea, post gastrointestinal surgery etc. Women in pregnancy or lactation; Can not be partners, such as the mentally ill; With alcohol or drug abuse; Enrolled in other trials; Any other conditions that researchers think not suitable for this experiment.;Exclusion criteria: Patients with malignant disease; Active autoimmune diseases; Acute or chronic infection disease, such as tuberculosis; Severe cardiovascular, brain, liver, or hematopoietic system disease; Serious gastrointestinal disease which affect drug absorption, such as active ulcer, chronic diarrhea, post gastrointestinal surgery etc. Women in pregnancy or lactation; Can not be partners, such as the mentally ill; With alcohol or drug abuse; Enrolled in other trials; Any other conditions that researchers think not suitable for this experiment.

Design outcomes

Primary

MeasureTime frame
dysfunction of AVF measured by vascular ultrasound;

Countries

China

Contacts

Public ContactXu Dongmei;Xu Dongmei;Xu Dongmei;Xu Dongmei;Xu Dongmei ;;;;

Shandong Provincial Qianfoshan Hospital;Shandong Provincial Qianfoshan Hospital;Shandong Provincial Qianfoshan Hospital;Shandong Provincial Qianfoshan Hospital;Shandong Provincial Qianfoshan Hospital

xudongmei63@163.com;xudongmei63@163.com;xudongmei63@163.com;xudongmei63@163.com;xudongmei63@163.com+86 0531 89268202;+86 0531 89268202;+86 0531 89268202;+86 0531 89268202;+86 0531 89268202

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026