postoperative cognitive dysfunction
Conditions
Interventions
M group:Preoperative intravenous injection of methylprednisolone
C group:Preoperative intravenous injection of the same amount of saline
Sponsors
The First Affiliated Hospital, University of South China
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Aged 65 to 75 years old; 2) Elective surgery for colorectal neoplasms; 3) American Association of Anesthesiologists (ASA) grade I to II; 4) Body mass index 18.5-23.9 kg / m2; 5) Heart function I-II grade; 6) Mallampati classification: I-II level; 7) Preoperative MoCA score = 26 points; 8) Sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Lung, liver, kidney vital organs dysfunction; 2) Patients who have had allergy in the case of a strong dragon or formula; 3) The history of anesthesia surgery in the past three months; 4) Previous history of mental illness, long-term use of anti-anxiety, antidepressants; 5) Preoperative MoCA examination confirmed the existence of cognitive dysfunction; 6) Illiteracy, hearing and speaking disabilities; 7) Certain infectious diseases with obvious symptoms, or certain viral diseases with obvious symptoms; 8) Can not communicate with patients and legal agents or follow-up after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction;MoCA score;MMSE score;Cog-12 score;WAIS score;Complement C3;Complement C5;5-HT;TNF-a;S100ß;NSE; | — |
Countries
China
Contacts
Public ContactLiu Wenjie
The First Affiliated Hospital,University of South China
Outcome results
None listed