Sterile femoral head necrosis
Conditions
Interventions
Indobufen cohort:oral Indobufen
Low molecular weight heparin cohort:hypodermic injection low-molecular-weight heparin
Sponsors
Hebei Medical University Third Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged 18-85 years old, weight> 55kg, male or female; (2) Patients with hip replacement surgery for various reasons; (3) VTE risk assessment = 3 points and = 15 points; (4) No history of lower limb vascular disease and negative finding by preoperative color Doppler examination of both lower extremity DVT; (5) The patient voluntarily signs the informed consent.
Exclusion criteria
Exclusion criteria: Subjects who meet one of the following exclusion criteria are not eligible to participate in this study: (1) Past thrombosis; (2) Platelets 2.5 times the upper limit of normal, plasma creatinine clearance> 1.25 times the upper limit of normal, plasma creatinine clearance <80ml / min); (9) Need to take long-term warfarin, the use of heparin and other anticoagulant patients; (10) Previously on indobufen, low molecular weight heparin has a history of allergies; (11) Severe heart failure; (12) Researchers believe that patients should not be selected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of DVT in both lower extremities; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of hemoglobin and platelet before and after treatment;;Hemorrhagic analysis of five indicators of the changes; | — |
Countries
China
Contacts
Public ContactYongtai Han
Hebei Medical University Third Hospital
Outcome results
None listed