pain
Conditions
Interventions
experimental group:Nalbuphine Hydrochloride
Sponsors
The 2nd Affiliated Hospital & Yuying Childrens Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 11 Years
Inclusion criteria
Inclusion criteria: 1. Aged 3-10 years male and female; 2. Body mass index (BMI) 24.5kg/m2=BMI=15.5kg/m2, and body weight above 12kg; 3. ASA anesthesia grade I-II; 4. Select the line of tonsil adenoidectomy in children (general anesthesia, non-complex local anesthesia); 5. Anesthesia operation time> 30min and <90min; 6. Children's parent or legal guardian sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to nalbupicin or its components, opioid allergy history children; 2. twenty four months before the use of analgesic sedatives, antiemetic drugs and anti-pruritus drugs; 3. twenty four hours before the body temperature higher than 38 degree C. or with acute upper respiratory tract infection symptoms of children; 4. Children with a history of bronchial asthma; 5. Preoperative diagnosis of severe sleep apnea syndrome in children; arrhythmia in children; 6. Preoperative assessment of difficult airway or previous abnormal history of anesthesia recovery; 7. Liver function damage (ALT and / or AST> 1.5 times the upper limit of normal reference) for renal dysfunction (BUN and / or Cr> normal reference) 8. 6 months with severe head trauma history, intracranial hypertension in children; 9. suffering from mental, neurological disease, and can not correctly express the wishes of children; 10. coagulation dysfunction (PT/TT higher than the upper limit of reference); 11. long-term sedative analgesic medication taking children; 12. Surgery time more than 1.5h or intraoperative additional anesthesia analgesics, sedative children; 13. Surgical blood loss greater than 100ml children; 14. Participated in other drug clinical trials in the past month; 15. Children who can not score FLACC for various reasons 16. Associated with other circumstances, the researchers think that is not suitable for selected children.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS scores; | — |
Countries
China
Contacts
Public ContactLiu Huacheng
The 2nd Affiliated Hospital & Yuying Childrens Hospital of Wenzhou Medical University
Outcome results
None listed