intrauterine adhesion
Conditions
Interventions
Study group:collagen scaffold
Control group: inertia ring
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) If the patient has frozen embryos, aged 20 to 45 years old; If the patient has no frozen embryos, aged 20 to 38 years old; 2) BMI < 30 kg/m2; 3) Hysteroscopy examination diagnosed Ashermen syndrome have amenorrhoea, the quantity is little, at least one symptom of infertility, and hysteroscopy or histologic diagnosis caused by intrauterine adhesions, accord with the standard of classification of the AFS1988 years class I or class II (grade 3 ~ 8 points); 4) Meet the WHO standards to the diagnosis of infertility; 5) Normal ovarian function; 6) Abortion or curettage surgery before operation, for the first time in at least one year, the menstrual cycle, the volume is normal; 7) Has a clear fertility intentions; 8) Negatie urine pregnancy test; 9) Agree to follow the research process and regular follow-up, signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Have not resolved by IVF infertility etiology, such as the genetic abnormality; 2) Hysteroscopy examination reealed barrel uterine cavity; 3) Simple endometrial thin, no caused by intrauterine adhesions. 4) Caused by intrauterine adhesions separation after simple endometrial scars; 5) Conception taboo disease;Influence uterine muscle intramural uterine fibroids or in the form of greater than 1 cm in diameter polyp;Stage III or IV endometriosis and uterine glandular myopathy. 6) History of malignancy, 7) Congenital malformation uterus and accessories and related operation history; 8) Coagulant function, liver and kidney dysfunction, or other researchers think that may affect the basis of research on diseases (uncontrolled hypertension, diabetes, sexually transmitted diseases, etc.); 9) Has been involved in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence of intrauterine adhesion;Endometrial thickness and blood flow; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Abortion rate; | — |
Countries
China
Contacts
Public ContactYli Hu
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed