portal hypertension and cirrhosis
Conditions
Interventions
Group 1:carvedilol 10mg bid
Group 2:propranolol 60mg bid
Sponsors
Drum Tower Hospital affiliated to Nanjing University Medicine School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old; 2. Tissue biopsy, or at least two imaging examinations, confirmed cirrhosis; 3. Endoscopic confirmation of moderate and severe esophageal and gastric varices; 4. ASevere gastroesophageal varices without bleeding(primary prevention)history of bleeding from esophageal varices or 5 days after acute bleeding (secondary prevention); 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Basal HVPG less than 12 mmHg; 2. The hepatic function of CTP is graded as grade C or severe ascites or severe hepatic failure; 3. Contraindications to ß-blockers, such as bronchial asthma, cardiogenic shock, heart block (II - III degree atrioventricular block), severe or acute heart failure and sinus bradycardia and allergic to this product etc; 4. Patients who takes drugs that affect the metabolism and absorption of non selective beta blockers in vivo; 5. Patients using other drugs that reduce portal pressure; 6. Patients with hepatocellular carcinoma or extrahepatic tumor, portal vein tumor thrombus, or thrombus; 7. Patients with severe heart, lung, liver, and kidney dysfunction, or severe hemorrhagic disease or local / systemic infection, hypothyroidism, Raynaud's syndrome, peripheral vascular disease, etc.; 8. Women who plans to become pregnant or pregnant or nursing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hepatic venous pressure gradient; | — |
Countries
China
Contacts
Public ContactYuzheng Zhuge
Drum Tower Hospital affiliated to Nanjing University Medicine School
Outcome results
None listed