Sepsis
Conditions
Interventions
Experimental:100ml Xuebijing Injection will be dissolved in 100 mL of normal saline every 12 hours for 5 days in blind fashion.
Placebo-controlled group:normal saline 200 ml every 12 hours for 5 days
Sponsors
ZhongDa Hospital, Affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sepsis-3 criteria from Society of Critical Care Medicine (SCCM) /European Society of Intensive Care Medicine (ESICM); 2. Aged 18 to 75 years; 3. SOFA 2 to 13; 4. obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. 48 hours after diagnosis of sepsis; 2. Pregnancy or lactating; 3. Severe Primary disease such as uncontrolled and metastasis malignancy, hematopathy, HIV; 4. Severe, preexisting, parenchymal liver dysfunction or kidney dysfunction with SOFA=3; 5. Previous immunodepressant within 6 months before study entry or Receipt of a solid-organ or bone marrow transplant; 6. Participation in an investigational clinical trial within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-Cause Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality in ICU;SOFA score;APACHE II;Duration of mechanical ventilation;ICU stay; | — |
Countries
China
Contacts
Public ContactHaiBo Qiu
ZhongDa Hospital, Affiliated to Southeast University
Outcome results
None listed