General surgery
Conditions
Interventions
rocuronium+dexmeitomidine:give the dexmeitomidine before anesthesia
rocuronium+saline solution:give the saline solution before anesthesia
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The first affiliated hospital of Wenzhou Medical university, 100 patients with elective general surgery, ASA grade I-II level, male and female, aged from 18 to 65 years old, weighing from 45 to 85 kg.
Exclusion criteria
Exclusion criteria: 1) severe bradycardia (heart rate <50 /min); 2) decompensated acute circulatory failure (mean arterial pressure <55mmHg); 3) II-III degree atrioventricular block; 4) serious systemic diseases such as hypertension, coronary heart disease, diabetes, chronic obstructive pulmonary disease and heart disease, renal insufficiency patients; 5) preoperative use of alpha 2 agonists and antagonists (such as clonidine) and cardiovascular drugs; 6) of Dex or its accessories allergy; 7) pregnancy Pregnancy and lactating women; 8) any other clinical trials in baseline within 3 months; 9) the researchers estimate should not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rocuronium concentration;Train Of Four ratio; circulation dynamics; | — |
Secondary
| Measure | Time frame |
|---|---|
| bispectral index; | — |
Countries
China
Contacts
Public ContactZhousheng Jin
The First Affiliated Hospital, Wenzhou Medical University
Outcome results
None listed