Pediarteric Disease
Conditions
Interventions
control group: saline
0.25ug/kg dexmedetomidine group:rapid injection of 0.25ug/kg dexmedetomidine and measure the oncentration
0.5ug/kg dexmedetomidine group:rapid injection of 0.5ug/kg dexmedetomidine and measure the oncentration
0.75ug/kg dexmedetomidine group:rapid injection of 0.75ug/kg dexmedetomidine and measure the oncentration
1.0ug/kg dexmedetomidine group:rapid injection of 1.0ug/kg dexmedetomidine and measure the oncentration
1.0ug/kg intranasal dexmedetomidine group:1.0ug/kg intranasal dexmedetomidine and measure the oncentration
1.5ug/kg intranasal dexmedetomidine group:1.5ug/kg intranasal dexmedetomidine and measure the oncentration
2.0ug/kg intranasal dexmedetomidine group:2.0ug/kg intranasal dexmedetomidine and measure the oncentration
Sponsors
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 9 Years
Inclusion criteria
Inclusion criteria: (1) selective operation of inguinal hernia repair,orthopedics operation or general surgery operation in children; (2) aged 3-9 years; (3) ASA I - II; (4) enter the operating room by himself without parents; (5) normal liver and kidney function; (6) no history of anesthesia medication allergy.
Exclusion criteria
Exclusion criteria: (1) allergic to dexmedetomidine, similar active ingredients or excipients; (2) G-6-PD deficiency; (3) a history of arrhythmia, bronchial and cardiovascular diseases, abnormal liver function and so on; (4) a history of use of alpha 2 receptor agonists or antagonists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;plasma concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emergence Agitation;blood pressure;Respiratory frequency;Tidal volume; | — |
Countries
China
Contacts
Public ContactFang Chen
The Scecond Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed