diabetes
Conditions
Interventions
Lifestyle intervention plus metformin:metformin + Lifestyle intervention
Sponsors
Second Andffiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. According to the classification standard of WHO glucose metabolism status (1999), IGR was diagnosed 2 weeks before randomization; 2. Aged 35 to 60 years; 3. Subjects who had not used hypoglycemic drugs (including herbal medicine for lowering blood sugar); 4. Women who are male or non-pregnant, non-lactating, and have no family planning for the next three years; 5. Body mass index (BMI) 24 kg/m2 = BMI < 32 kg/m2; 6. Written informed consent has been signed prior to the start of the experiment.
Exclusion criteria
Exclusion criteria: 1. Medications that affect glucose metabolism for the treatment of pre-existing conditions (not including daily doses of no more than 12.5 mg of thiazide diuretics); 2. Have taken weight-loss drugs (including traditional Chinese medicine) during 6 months and during the intervention. Currently take two or more blood pressure drugs; 4. Diabetic patients; 5. Within 3 months before the screening visit the following cardiovascular symptoms: acute myocardial infarction (mi), New York heart association III/IV level of the definition of congestive heart failure, left ventricular ejection fraction of 40% or less, or cerebrovascular accident; 6. Hypertension after treatment (systolic pressure is greater than 160mmHg, or diastolic pressure is greater than 105mmHg); 7. Liver function is impaired, and the clinical signs or symptoms of obvious liver disease have appeared, acute or chronic hepatitis, and the ALT or AST levels are 2.5 times higher than the upper limit of reference range; 8. Renal insufficiency (eGFR < 45ml/min); 9. Patients using a ventilator; 10. Allergic to metformin or any of the auxiliary materials (e.g. povidone K30, magnesium stearate and hydroxypropyl cellulose); 11. Suffering from an illness that may lead to hypoxia (particularly acute or chronic respiratory diseases); 12. Acute intoxication and alcoholism; 13. Severe chronic gastrointestinal disease; 14. Severe mental illness; 15. Cancer that needs treatment within five years; 16. Thyroid disease that is not effectively controlled; 17. Pregnant or lactating women; 18. Other clinical trials have been performed in the last 30 days; 19. The researchers believe that the subjects are not suitable for other important diseases in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose;Endothelial progenitor cell; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;insulin; | — |
Countries
China
Contacts
Public ContactPing Yu
Second Andffiliated Hospital of Harbin Medical University
Outcome results
None listed