Blood-sparing efficacy of multiple doses of oral tranexamic acid administration in enhanced-recovery primary total knee arthroplasty:a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-17012265

Enrollment

Unknown

Registered

2017-08-10

Start date

2017-08-31

Completion date

Unknown

Last updated

2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

A:2g ora TXA 2h preoperatively

B:2g oral TXA 2h preoperatively, and 1g oral TXA 3h postoperatively

C:2g oral TXA 2h preoperatively, and 1g oral TXA 3h and 9h postoperatively

D:2g oral TXA 2h preoperatively, and 1g oral TXA 3h, 9h, and 15h postoperatively

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients following primary total knee arthroplasty due to osteoarthritis; (2) Patinets with preoperative platelet and coagulation function dysfunction; (3) Preoperative double lower limb venous color Doppler ultrasound was not abnormal; (4) voluntarily participated in clinical trials and signed informed consent, good compliance of patients.

Exclusion criteria

Exclusion criteria: (1) Patinets with history of venous thromboembolism, pulmonary embolism, cerebral infarction, coronary heart disease; (2) Patients with coagulation disorders; (3) Anticoagulant drugs are being used; (4) Administration of NSAID for less than 1 weeks; (5) TXA allergy; (6) Severe liver and renal insufficiency; (7) Patients with high risk of thrombosis, including atrial fibrillation, cardiac pacemaker, and stent implantation.

Design outcomes

Primary

Measure	Time frame
Total blood loss;	—

Secondary

Measure	Time frame
Hb;HCT;D-Dimer;Fibrin degradation products;Allogeneic blood transfusion rate;DVT;PE;Wound complications;Other adverse events;Intraoperative blood loss;IV fluid;Hidden blood loss;	—

Countries

China

Contacts

Public ContactZhou Zongke

West China Hospital, Sichuan University

zongke@126.com+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026