General anesthesia of laparoscopic surgery
Conditions
Interventions
Group D:Intravenous infusion of dexmedetomidine before induction of anesthesia
Group C:Intravenous infusion of same volume normal saline before induction of anesthesia
Sponsors
Department of Anesthesiology, Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 68 Years
Inclusion criteria
Inclusion criteria: Forty patients with American Society of Anesthesiologists (ASA) I or II, scheduled for elective laparoscopic surgery under general anesthesia,all genders, aged 18-68 years,body mass index less than 30 kg/m2, with normal hepatic or renal function, without uncontrolled hypertension and/or diabetes mellitus, severe heart and lung diseases, and signed informed consent form before anesthesia, will be prospectively studied.
Exclusion criteria
Exclusion criteria: Patients with a history of allergy to dexmedetomidine, severe cardiac conduction block, evidence of pregnancy, a (family) history of malignant hyperthermia, having drug and alcohol dependency, refused to sign an informed consent form, or total time of target-controlled infusion of sufentanil is more than 4 hours, will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood cortisol concentration;Hemodynamic changes;Blood glucose concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood C-reactive protein concentration;blood gas analysis;Recovery profile;Adverse effect; | — |
Countries
China
Contacts
Public ContactYan Zhao
Department of Anesthesiology, Peking University Third Hospital
Outcome results
None listed