Ischemic stroke
Conditions
Interventions
control group:thrombolytic therapy or combined with intravenous thrombolysis and endovascular
experiment group:use BBB protective agents after thrombolytic therapy or combined with intravenous thrombolysis and endovascular
Sponsors
Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-80 years old; 2) diagnosis of ischemic stroke, and with evaluable neurologic impairment, except bleeding by CT head; 3) within 4.5 hours of onset; 4) onset or previous stroke without obvious sequelae (mRS = 2); 5) stroke symptoms continued 30min at least, no significant improvement before treatment; 6) agreed to accept thrombolytic therapy or combined with intravenous thrombolysis and endovascular, and agree with the history data collection, preservation and follow-up, signed informed consent; 7) be willing and able to follow the research plan.
Exclusion criteria
Exclusion criteria: 1) do not agree to receive intravenous thrombolysis, intravenous thrombolysis and endovascular treatment; 2) with significant sequelae (mRS>2) in past stroke; 3) cannot use routine blood brain barrier protective agents due to contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological function test;Cognitive function test;CT head; | — |
Countries
China
Contacts
Public ContactYUN XU
Affiliated Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed