The effect of thiamine and folate transporters on oxidative stress and cognitive function in chronic kidney disease

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-17012210

Enrollment

Unknown

Registered

2017-08-01

Start date

2017-08-15

Completion date

Unknown

Last updated

2017-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease and cognitive impairment

Interventions

intervention group:thiamine

intervention group:folic acid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Maintenance dialysis includes hemodialysis or peritoneal dialysis(>=3 months); 2) suffered cognitive impairment. Definition: MMSE scoring ?17 points for illiterate, ?20 points for primary, ?24 points for secondary school, or MoCA score <26 points; 3) Aged 18-75 years old, male or female; 4) Informed Consent Form.

Exclusion criteria

Exclusion criteria: 1) The patient's medical records are missing or incomplete; 2) Unable to cooperate with the completion of this clinical trial; 3) Lifespan less than one year; 4) Participated in other clinical trials in three months; 5) Patients with severe anemia, infection, tumor, active bleeding and heart, lung or liver function failure; 6) Allergic with Thiamine or folic acid.

Design outcomes

Primary

Measure	Time frame
cognitive function assessment;Serum thiamin;plasma folic acid;Plasma homocysteine;	—

Countries

China

Contacts

Public ContactRenhua Lu

Renji Hospital, School of Medicine, Shanghai Jiao Tong University

lurenhua1977@hotmail.com+86 13361958582

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026