Chronic Hepatitis B
Conditions
Interventions
Sponsors
Shenzhen Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients meet the diagnostic criteria for chronic HBV carriers (1) serum HBsAg, HBeAg and HBV-DNA are positive; (2) patients are fluped 3 times in one year, whose serum ALT, AST are within the normal range; c. Liver histological examination shows no obvious abnormalities.); 2. The differentiation of traditional Chinese medicine meets spleen-kidney deficiency syndrome; 3. Aged between 30-65 years, patients have been infected HBV for more than 20 years; 4. Serum ALT = 40u/L; 5. Serum HBV-DNA: >10^5copies/ml, 10 IU/ml, <105 IU/ml; 7. Patient sign the informed consents and volunteer to participate in this clinical trial.
Exclusion criteria
Exclusion criteria: 1) Patients infect HIV, HCV and HDV; 2) Patients with metabolic or autoimmune liver disease; 3) Patients have a history of alcohol abuse or illicit drugs or participate in other clinical trials of hepatitis drugs within 30 days; 4) Serum ALT and AST levels show abnormality with one years; 5) Patients are treated with nucleoside or interferon for 24 weeks prior to enrollment; 6) Inactive HBsAg carriers; 7) Patients with cirrhosis or patients' AFP are increased; 8) Pregnant or lactating women; 9) Patients with mental disease and other serious organ diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum HBV-DNA;HBeAg seroconversion;HBsAg seroconversion;Serum ALT;Knodell HAI score;Ishak fibrosis score; | — |
Countries
China
Contacts
Public ContactDaqiao Zhou
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed