The influence of volatile induction and maintenance anesthesia with sevoflurane and desflurane on postoperative agitation, delirium and cognitive disorder in pediatric anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-17011915

Enrollment

Unknown

Registered

2017-07-09

Start date

2017-11-01

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

paediatric postoperative cognitive disorder

Interventions

S group:volatile induction and maintenance anesthesia(VIMA) with sevoflurane

SD group:desflurane anesthesia after sevoflurane inhaled induction

SP group:propofol intravenous maintenance after sevoflurane inhaled induction

P group:total intravenous anesthesia?(TIVA) with propofol

PD group:desflurane inhaled maintenance after propofol induction

Eligibility

Sex/Gender

All

Age

5 Years to 12 Years

Inclusion criteria

Inclusion criteria: 1. children aged 5-12 years; 2. scheduled to undergo elective adenotossillectomy and/or Adenoidectomy; 3. children with American Society of Anesthesiologists (ASA) physical status I or II; 4. intelligence quotient(IQ) = 90 under preoperative Peabody Picture Vocabulary Test(PPVT); 5. signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. children with developmental delay, mental retardation, dysgnosia and language disorders; 2. children with neurological disorders or psychiatric illness before the surgery; 3. children with cardiovascular, respiratory, hapatic, renal, endocrine,or immuce diseases; 4. children with abnormal airway, asthma or other reactive airway disease; 5. children with history of general anesthesia or long time exposure to general anesthesia before the surgery; 6.children without any premedication(e.g. anticholinergic agents or sedative-hypnotic drugs, etc.); 7.communication or follow-up problems with inspector of children.

Design outcomes

Primary

Measure	Time frame
the incidence of emergence agitation;the 5-point scale score ;pediatric anesthesia emergence delirium( PAED)scale;Children's and Infants' Postoperative Pain Scale (CHIPPS);Face, Legs, Activity, Cry, Consolability (FLACC) scale;Peabody Picture Vocabulary Test (PPVT);Combined Raven's Test (CRT);Wechsler intelligence scale for children ;S100ß;neuron-specific enolase (NSE) ;	—

Countries

China

Contacts

Public ContactLiu Wenjie

The First Affiliated Hospital, University of South China

149144040@qq.com+86 13037344744

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026