Parkinson's Disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. a clear diagnosis of primary Parkinson's disease, Meet the 2013 Criteria of Guidelines for the diagnosis of Parkinson 's disease of European Neurological Union: 1) reduced capasity of movement; 2) meets at least one of the following clinical manifestations, including muscle rigidity; resting tremor; posture instability. 3) at least meet the following criteria: unilateral disease; resting tremor; disease progressively progress; after the onset of persistent asymmetric involvement; levodopa treatment at first effective; 2. Hoehn-Yahr grade 1-3, able to walk independently; 3. 1 week before the election to the beginning of the trial did not adjust the drug, medication during treatment unchanged; 4. auditory, visual and cognitive ability is normal.
Exclusion criteria
Exclusion criteria: (1) various secondary Parkinson's syndrome (including traumatic, drug-induced, tumor, vascular, toxic, hydrocephalus, etc.) and Parkinson's syndrome; (2) previous bone and joint disease or cerebrovascular disease, and the impact of walking or balance function; (3) heart failure, severe hypertension and other serious medical diseases; (4) do not cooperate with the inspection and training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The bulk sensory mean index (A.T.E);Gait test results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson’S Disease Rating Scale,UPDRS;Serum Tyrosine hydroxylase,TH;Serum HVA;Serum alpha-synuclein; | — |
Countries
China
Contacts
Affiliated Lianyungang Hospital of Xuzhou Medical University