gastroesophageal reflux disease
Conditions
Interventions
Group A:Omeprazole Enteric-coated Capsules
Group B:Esomeprazole Magnesium Enteric-coated Tablets
Group C:Omeprazole Enteric-coated Capsules and Itopride Hydrochloride Tablets
Sponsors
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine,Z hejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18-70 years old, male or female; (2) Gastroscopy is consistent with RE (A/B class) or non-esophageal mucosal injury (Los Angeles classification criteria) but with typical reflux, heartburn, post-sternal pain and other symptoms, and the duration of the disease is greater than 2 months, and the gerd-Q scale score is greater than 8; (3) Patients who have not taken antacids, prokinetic drugs or gastric mucosal protective agents within two weeks prior to enrollment ointestinal power were not taken in 2 weeks.
Exclusion criteria
Exclusion criteria: (1) Pregnant and lactating women; (2) severe heart, lung, liver, renal insufficiency, blood, endocrine disease, connective tissue disease and other malignant diseases; (3) there is a history of gastrointestinal surgery or other diseases such as cardiac atonia, intestinal obstruction and ulcerative colitis; (4) gastroscopy has the ability of other organic diseases such as peptic ulcer and gastric cancer; (5) have a history of drug allergy or mental illness; (6) do not cooperate with the treatment, do not follow the diagnosis on time or do not wish to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GERD-Q;External symptom assessment of esophagus;gastroscope;esophageal motility test;48 hours PH + impedance;GAD-7;PHG-9; | — |
Countries
China
Contacts
Public ContactNing Dai
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine,Z hejiang University
Outcome results
None listed