The clinical effect of oral Tranexamic acid in peri-operative period of total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-17011848

Enrollment

Unknown

Registered

2017-07-03

Start date

2017-09-30

Completion date

Unknown

Last updated

2017-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

A:2g po TXA before surgery, 2g po TXA 3, 9 hours later

B:2g po TXA before surgery, 2g po TXA 3, 9 hours later, 2g po with a 24h interval to discharge, 1g po txa to POD-14

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Primary unilateral total knee artropasty; (2) Normal platelet and coagulation function preoperatively; (3) Normal intravenous ultrasound in the lower extremities preoperatively; (4) Able and willing to provide signed informed consent

Exclusion criteria

Exclusion criteria: (1) Systemic infections such as pulmonary infection or urinary tract infection are not controlled preoperatively; (2) Abnormal immune function or combined immune-related disease preoperatively; (3) Abnormal inflammatory index preoperatively (C-reactive protein >20 mg/L); (4) Abnormal fibrinolysis index preoperatively (FDP > 5mg/L); (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) Allergy to tranexamic acid (TXA) or dexamethasone or have contraindications; (7) Patients at high risk of thrombosis; (8) History of deep vein thrombosis (VTE, calf muscle vein thrombosis or superficial vein thrombosis, pulmonary embolism); (9) serious liver and kidney dysfunction.

Design outcomes

Primary

Measure	Time frame
haemoglobin level;Blood loss;kss;Transfusion;ESR, CRP, IL-6;ROM; deep vein thrombosis ;cost;sweeling;nausea and vomiting;ecchymosis;length of hospital stay;pain;	—

Countries

China

Contacts

Public ContactZhou Zongke

West China Hospital, Sichuan University

zongke@126.com+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026