Rett syndrome
Conditions
Interventions
intervention:VNS treatment
control:fake treatment of VNS
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. aged 3-6 years old; 2. meet the diagnostic criteria for Rett syndrome; 3. with the use of vagus nerve stimulator treatment indications; 4. subjects and their families can fully understand the therapy and the signing of informed consent; 5. subjects and their families can complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. surgical and anesthesia practitioners identified contraindications for surgery, including cancer, arrhythmia, heart failure, progressive neurological diseases, asthma, mental illness, peptic ulcer, insulin-dependent diabetes mellitus or poor physical condition; 2. side or bilateral vagus nerve lesions or damage; 3. at the same time undergoing other drugs or equipment clinical trials; 4. preoperative examination is incomplete; 5. patients who is infection in the 7 days before surgery to the day of surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Severity Scale;Clinical Global Impression Scale;Gesell Developmental Scale;128 Channel EEG;Eyetracking; | — |
Secondary
| Measure | Time frame |
|---|---|
| electrocardiogram; | — |
Countries
China
Contacts
Public ContactLi-Ping Zou
The Paediatrics Center of PLA General Hospital
Outcome results
None listed