radiation-induced oral mucositis
Conditions
Interventions
Drug Group :thalidomide (75mg, qn) and mouthwash from Day 1 of radiation therapy to week 6-7
Control Group:mouthwash from Day 1 of radiation therapy to week 6-7
Sponsors
Sixth Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. Patients with histologically locally advanced NPC; 3. willing to accept the treatment as this study provide; 4. KPS score of 70 or more; 5. reexamination on time; 6. fill out the scales by self or with others help; 7. Adequate hematologic function (PLT=70×109 per liter;ANC=1.5×109 per liter); 8. sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Women during Pregnancy, breastfeeding or those of childbearing age who do not want to take contraceptive measures; 2. Patients with any Mental problem; 3. Patients with substance abuse or alcohol abuse; 4. Patients with some other certain oral diseases; 5. Patients recieved glucocorticoids or immunosuppressor in the last month; 6. Patients Allergic to the drug ingredients; 7. Patients had Participated in other drug clinical trials in the past 4 weeks; 8. Patients had a history of venous or arterial thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale(VAS);RTOG Grade; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reactions;quality of life;drug combination; | — |
Countries
China
Contacts
Public ContactLeifeng, Liang
Sixth Affiliated Hospital of Guangxi Medical University
Outcome results
None listed