postoperative gastrointestinal function in patients undergoing gynecological malignant tumor radical surgery
Conditions
Interventions
Experimental group:Perioperative using nalbuphine for perioperative analgesia
control group:Perioperative using sufentanil for perioperative analgesia
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. patients aging 18-70 years old, udergoing laparoscopic gynecological malignancy radical surgery; 2. patients with ASA ranging from grade I to grade II.
Exclusion criteria
Exclusion criteria: 1. patient with opioid allergy; 2. patient with preoperative liver dysfunction (ALT> 66U/L or AST> 36U/L); 3. patient with preoperative renal dysfunction (creatinine> 106umol/L or urea nitrogen> 6.1mmol/L); 4. patient with abnormal history of abnormal anesthesia; 5. patient with esophageal reflux disease; 6. patient who used sedatives or antiemetic medicine in 24 hours; 7. Shock patient; 8. patients with chronic obstructive pulmonary disease (COPD); 9. patient who can not understand the visual fuzzy score (VAS); 10. patient who can not understand how to use intravenous controlled analgesia (PCA); 11. patients refusing to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First exhaust time;First defecation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| First time to eat;The number of nausea during postoperative 48 hours;The number of vomit during postoperative 48 hours;VAS score at 6 hours after operation;VAS score at 12 hours after operation;VAS score at 24 hours after operation;VAS score at 48 hours after operation;Number of hospitalized days;Serum gastrin measured 24 hours before and after surgery; | — |
Countries
China
Contacts
Public ContactJiao Jing
Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed