Infertility, obesity
Conditions
Interventions
Orlistat group:Orlistat treatment for 1-3 months
Placebo group:Placebo treatment for 1-3 months
Sponsors
Center for Reproductive Medicine Affiliated to Shandong University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. women aged 20-40 years old; 2. women with the body mass index =25kg/m2; 3. women who undergo cycle of IVF or ICSI.
Exclusion criteria
Exclusion criteria: 1. women who had failed in 3 or more IVF cycles; 2. women diagnosed with uterine malformation or abnormality by ultrasound or severe intrauterine adhesion by hysteroscope; 3. women with abnormal liver or renal function; 4. women who is allergic to orlistat; 5. women who had chronic malabsorption syndrome or intrahepatic cholestasis; 6. women who had organic obesity (e.g., hypothyroidism).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| height;weight;waistline;hipline;blood glucose level;blood insulin level;blood lipid level;dosage of exogenous gonadotrophic hormone;number of retrieved oocytes;number of transferred embryos on D3;biochemical pregnancy rate;clinical pregnancy rate;ongoing pregnancy rate;miscarriage rate;premature delivery rate;congenital malformation rate;incidence of gestational diabetes;incidence of pre-eclampsia;incidence of placental abruption;incidence of premature rupture of membranes;stillbirth rate;incidence of neonatal jaundice;incidence of neonatal infection;incidence of neonatal hospitalization for more than 3 days;OHSS rate;birth weight of newborn; | — |
Countries
China
Contacts
Public ContactZi-Jiang Chen
Center for Reproductive Medicine Affiliated to Shandong University
Outcome results
None listed