recurrent aphthous ulceration
Conditions
Interventions
control group :prednisone
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1) aged 18-59 years; 2) history of recurrent aphthous ulceration longer than 6 months and intermission less than 2days,duration less than 3 days; 3) negative reaction to pregnancy test in women with no reproductive plans or menopause; 4) men with no reproductive plans for at least 3 months; 5) no abnormal with vital signs, routine physical examination and neurofunctional tests.
Exclusion criteria
Exclusion criteria: (1) pregnancy, intention of pregnancy, lactation; (2) people with peripheral neuropathy; (3) presence of severe oral mucosal diseases; (4) history of allergies to thalidomide and prednisone or a known history of serious drug hypersensitivity; (5) presence of severe systemic diseases; (6) use of systemic corticosteroids for the treatment of any diseases within 1 month or drugs that affect immune function within 3 months before study entry; (7) addiction to smoking and alcohol; (8) participation in any other clinical trials in the 3 months before enrollment in this study; (9) people do not follow the doctor's advice or be on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intermission;frequency of recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain level;average number of ulcers;average period of the ulcers; | — |
Countries
China
Contacts
Public ContactHongmei Zhou
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed