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Therapeutic effects of Salvia miltiorrhiza injection combined with Telmisartan in patients with diabetic nephropathy by influencing collagen IV and Fibronectin

Therapeutic effects of Salvia miltiorrhiza injection combined with Telmisartan in patients with diabetic nephropathy by influencing collagen IV and Fibronectin

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IPR-17011581
Enrollment
Unknown
Registered
2017-06-06
Start date
2014-01-01
Completion date
Unknown
Last updated
2017-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic nephropathy

Interventions

telmisartan group (T group) :patients in the telmisartan group (T group) were given oral telmisartan at a dose of 40 mg daily for 4 weeks
Salvia miltiorrhiza injection + telmisartan (S + T group):patients in the Salvia miltiorrhiza injection + telmisartan (S + T group) were administered with Salvia miltiorrhiza injection combined with t

Sponsors

The Third Affiliated Hospital of Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
36 Years to 72 Years

Inclusion criteria

Inclusion criteria: (1) patients with clear history of diabetes; (2) urinary albumin excretion rate > 20 g/min (30 mg/L), or positive urinary protein or 24 hour urine quantitative protein > 0.5 g determined by conventional detection method; (3) patients with mild renal function (serum creatinine < 265 umol/L); (4) patients who met the above diagnosis criteria; (5) patients aged from 18 to 70 years old.

Exclusion criteria

Exclusion criteria: (1) patients who were clinically confirmed with nephritis, urinary tract infection, renal vascular disease and urinary tract obstruction diseases that could cause proteinuria; (2) pregnant or lactating women; (3) patients who had grievously heart, liver, renal dysfunction; (4) patients with thyroid disease, Cushing disease and other diseases of the endocrine system; (5) patients of allergic constitution or allergic to the present medicine; (6) psychiatric patients and who were unable to cooperate properly.

Design outcomes

Primary

MeasureTime frame
Collagen IV;Fibronectin;

Countries

China

Contacts

Public ContactNie Jieming

The Third Affiliated Hospital of Guangzhou Medical University

n1360977@163.com+86 13609776031

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026