amnestic mild cognitive impairment
Conditions
Interventions
Dengzhan Shengmai Capsule group:Basic treatment and Dengzhan Shengmai Capsule
Placebo control group:Basic treatment and placebo Capsule
Sponsors
Centre for Beijing Aging Brain Rejuvenation initiative, Beijing Normal University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged between 50 to 80 years; 2) Education level > 6 years; 3) aMCI diagnosis in line with Petersen diagnostic criteria; 4) normal daily basic functions Complex instrumental routine functions can be slightly damaged; 5) No dementia; 6) 18F-AV45 PET imaging showed Aß deposition was positive or nuclear magnetic resonance imaging showed hippocampal atrophy; 7) subjects or legal guardian sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) transient ischemic attack (TIA); 2) cerebral hemorrhage or subarachnoid hemorrhage; 3) confirmed by the brain tumor, brain trauma, blood disease caused by stroke subjects; 4) due to rheumatic heart disease, coronary heart disease and other heart disease with atrial fibrillation, caused by cerebral embolism; 5) combined with liver, kidney, hematopoietic system, endocrine system and other serious diseases and bone and joint disease; 6) mental disorders or severe dementia; 7) subjects undergoing cardiac pacemaker surgery, coronary intervention, and coronary artery bypass surgery, who were not eligible for MRI; 8) Subjects who have magnetic intra-articular implants and who can not undergo magnetic resonance imaging; 9) Allergy to this test drug; 10) taking drugs to improve brain function (such as cholinase inhibitors) and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's disease assessment scale, ADAS-cog;Auditory Verbal Learning Test, AVLT;activate value of brain region in resting state;Network value of white matter fiber tracts;Aß protein deposition of brain tissue (SUV);glucose metabolism of brain tissue;blood coagulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental Status Examination, MMSE;Montreal Cognitive Assessment scale, MoCA;Rey-Osterrich Complex Figure Test;activity of daily living;Trail Making Test;Clock Drawing Test;Symbol Digit Modalities Test;Verbal Fluency Test;Boston Naming Test; | — |
Countries
China
Contacts
Public ContactZhanJun ZHANG
Centre for Beijing Aging Brain Rejuvenation initiative, Beijing Normal University
Outcome results
None listed