cervical cancer
Conditions
Interventions
1:Human recombinant endostatin (Endostar) combined with concurrent radiochemotherapy
2:concurrent radiochemotherapy
Sponsors
The Cancer Hospital of Gansu Province
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 70 years old; 2. KPS grade 80-90; 3. The disease was diagnosed as cervical carcinoma with histopathology and cytology; Pathologic types include squamous cell carcinoma and adenocarcinoma; 4. FIGO stage IIB ~ IVb; 5. The laboratory criteria: the blood routine, liver, kidney function and heart function are basically normal, WBC?4*10^9/L; neutrophil? 2*10^9/L; platelet ? 100*10^9/L; Hemoglobin?90g/L; 6. Expected survival =12weeks; 7. Voluntary participation and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The history of allergy to biological agents; 2. Undering Other anti-cancer treatments; 3. other as following : History of important viscera dysfunction and severe heart disease including congestive heart failure,arrhythmia, beyond the control of the require long-term drug treatment of angina pectoris, heart valve disease, myocardial infarction, and patients with resistant hypertension, pregnancy or lactation women, infective wound in delay no more, have the spirit of not easy to control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Respond Rate;Progression-free Survival, PFS;Overall Survival, OS;Toxity and side-effect; | — |
Countries
China
Contacts
Public ContactFengju Zhao
The Cancer Hospital of Gansu Province
Outcome results
None listed