Acute myeloid leukemia
Conditions
Interventions
study group:prophylactic Levofloxacin
control group:no prophylactic antibiotics
Sponsors
Rui Jin hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute of Hematology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. AML patients; 2. To be aged 18-60 years; 3. hepatic and renal function: Total bilirubine=35umol/L,AST/ALT less than 2 times of normal upper limit,creatinine<=150umol/L; 4. Normal cardiac function NYHA I/II; 5.Performance status: Eastern Cooperative Oncology Group (ECOG) 0-2; 6. no former chemotherapy before induction; 7. Non-pregnant and non-nursing; 8. Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test to rule out pregnancy; 9. written informed consent signed.
Exclusion criteria
Exclusion criteria: 1. Previous MDS history, treatment related AML; 2. Previously treated patients; 3. Allergy to any medication in the regimen; 4. Liver and renal insufficiency (beyond the inclusion criteria); 5. Patients with ejection fraction 2); 6. Patients with a "currently active" second malignancy; 7. Patients with "currently active" tuberculosis. Patients with HIV;active HBV, HCV, or Hepatitis A infection; 8. Patients with other hematological disease (including disturbance of blood coagulation not caused by AML); 9. Patients who can't understand or obey the protocol; 10. patient obtained chemotherapy and/or antibiotics during the latest three months; 11. patients with evidence of infection at the time of admission; 12. Other circumstance that obstructs the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| event free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| febrile duration;gut microbiome diversity; | — |
Countries
China
Contacts
Public ContactJunmin Li
Rui Jin hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute of Hematology
Outcome results
None listed