Parkinson’s disease
Conditions
Interventions
treatment group:dihydroergotoxine mesylate 2.5 mg, twice daily, two weeks
intervention group:identical placebo 2.5 mg, twice daily, two weeks
Sponsors
Nanjing First Hospital Affiliated to Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients were diagnosed with idiopathic PD according to the UK Parkinsons Disease Society Brain Bank criteria; 2. Patients were required to have obvious to severe sialorrhea (United Parkinsons Disease Rating Scale [UPDRS] part II [item 6] salivation score rating of three or higher); 3. patients should be at least 18 years old; 4. patient or a caregiver had to be able to score the extent of sialorrhea on a daily basis.
Exclusion criteria
Exclusion criteria: 1. sialorrhea caused by factors other than PD (e.g. badly fitted dentures); 2. a known hypersensitivity to dihydroergotoxine mesylate; 3. BoNT for drooling within the past three months; 4. symptomatic bradycardia, severe postural hypotension, symptomatic coronary insufficiency, severe organic heart damage, severe hepatic and renal dysfunction, active psychosis, and pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Sialorrhea Clinical Scale for PD (SCS-PD); | — |
Secondary
| Measure | Time frame |
|---|---|
| (United Parkinson’s Disease Rating Scale; | — |
Countries
China
Contacts
Public ContactYouyong Tian
Nanjing First Hospital Affiliated to Nanjing Medical University
Outcome results
None listed