open radical gastrectomy
Conditions
Interventions
Dex group:Dexmedetomidine 0.5 ug/kg was intravenously infused over 10 minutes before anesthesia induction, followed by a rate of 0.5 ug/kg/h until peritoneal closure
Con group:Volume-matched normal saline
Sponsors
Affiliated People's Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: ASA I or II, aged =70 year.
Exclusion criteria
Exclusion criteria: BMI=28 kg/m2, preoperative coagulation disorder, abnormal platelet count, hepatic and renal insufficiency, any kind of preoperative medication that interfere with coagulation, heart disorder and preoperative blood transfusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TEG;Standard coagulation function;The activity of plasma AT-III;The concentrations of protein C and s-TM;The concentrations of plasma PAP and t-PA and PAI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematocrit and platelet count;The requirements of intraoperative propofol and remifentanil; | — |
Countries
China
Contacts
Public ContactShao Dong-Hua
Affiliated People's Hospital of Jiangsu University
Outcome results
None listed