Lung cancer
Conditions
Interventions
dexmedetomidine group:dexmedetomidine
Control:Placebo
Sponsors
The First Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
Male
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Selected patients with thoracoscopic lobectomy for epidural anesthesia combined with general anesthesia, and the operative time are 2-4 hours; 2. aged more than 65 years old, male, ASA grade I or II , body mass index (BMI) 18-24kg/m2; 3. According to the disease history, physical examination, laboratory examination, no serious heart and lung, liver and kidney disease, no signs of difficult intubation, no obvious mental disorders and sedative hypnotic drug use history; 4. Preoperative cognitive function was normal.
Exclusion criteria
Exclusion criteria: 1. In the past, there were mental diseases, nervous system diseases, traumatic brain injury and mental disorders; 2. Patients with preoperative cognitive impairment or cognitive factors that have an effect on cognitive function; 3. Disturbance of acid-base balance of water and electrolyte, abnormal coagulation, the existence of epidural anesthesia contraindications; 4. The sedative hypnotic drugs and substance abuse, Parkinson's disease, alcoholism, alcohol or drug addiction; 5. There is a serious diseases of heart, lung, liver and kidney dysfunction and immune system diseases, endocrine immune system or may interfere with the results of any other disease or pathology; 6. The existence of serious vision, hearing or language barrier to complete the test of patients; 7. The known hypersensitivity to drug research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BIS;BIS;SR;IL-1ß;TNF-a;S100ß; | — |
Countries
China
Contacts
Public ContactShi Haixia
The First Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed