acute lung injury
Conditions
Interventions
Adults Control group:adminster the saline in the same manner as dextomedetomidine in Group B
Adults Dextomedetomidine group:A bolus dose of dexmedetomidine with 1.0ug/kg for 15 min before the induction of anesthesia then continued infusion at 0.5 ug/kg/h until the end of the surgery
Children Control group:adminster the saline in the same manner as dextomedetomidine in Group D
Children Dextomedetomidine group:A bolus dose of dexmedetomidine with 1.0ug/kg for 15 min before the induction of anesthesia then continued infusion at 0.5 ug/kg/h until the end of the surgery
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. aged 1 to 65 years; 2. American Society of Anaesthesiologists physical status from 1 to 3; 3. Expected duration of surgery undergoing General anesthesia shorter than at least 5 hour; 4. Local is less than 2500 meters above sea level.
Exclusion criteria
Exclusion criteria: 1. medication with anticoagulants within the previous less than 3 days; 2. Redo heart surgery; 3. Severe heamatological diseases and endocrine system diseases; 4. Severe arrhythmia; 5. with renal insufficiency or Liver dysfunction or pre-operative coagulation disorders; 6. pulmonary disease,such as pulmonary hypertensionchronic bronchitis or pulmonary infectious diseases; 7. Heparin-resistant, heparin-induced thrombocytopenia syndrome; 8. Cardiac resuscitation is difficult(defibrillation>4 times); 9. Surgery undergoing General anesthesia longer than at least 5 hour; 10. Chronic heart failure or tetralogy of Fallo (TOF).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamics;IL-6;IL-8;ICOM-1;TNFalpha;Cortisol;Norepinephrine;Adrenaline; | — |
Countries
China
Contacts
Public ContactZhang Hong
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed