Obesity complicated by hyperlipidemia
Conditions
Interventions
1:Simvastatin group
2:Orlistat-Simvastatin group
Sponsors
Beijing Anzhen Hospital Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years old; 2. Body mass index (BMI) 24-40; 3. Total cholesterol(TC) =6.22 mmol/L; 4. Triglyceride(TG)=2.26 mmol/L; 5. High density lipoprotein cholesterol (HDL-c)<1.0 mmol/L; 6. Low density lipoprotein cholesterol (LDL-c)=3.12 mmol/L. Both 1 and 2at least one of 3.4.5.6 items at the same time.
Exclusion criteria
Exclusion criteria: 1. Weight loss or rise more than 4 kg in nearly three months, 2. Diabetes; 3. Patients with congenital heart disease, rheumatic heart disease, acute or chronic renal insufficiency, severe liver active disease; 4. Patients with a history of myocardial infarction or unstable angina within 3 months before research, 5. Patients with a history of recurrent gallstones or kidney stones, 6. Patients who had been diagnosed with postoperative intestinal adhesion, 7. Patients with peptic ulcer or malabsorption syndrome; 8. Patients with a history of pancreatitis; 9. ALT or AST ? 2.5 times of normal level; 10. Patients with malignant tumor and HIV positive; 11. Psychiatric patients; 12. Patients with a history of hyperthyroidism appetite and laxation drug abuse; 13. Subjects who accept other study drugs in recent three months; 14. Researchers think that the subject who are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight;Body mass index (BMI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Total cholesterol(TC);Triglyceride(TG);High density lipoprotein cholesterol (HDL-c);Low density lipoprotein cholesterol (LDL-c); | — |
Countries
China
Contacts
Public ContactWang Zuoguang
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed