Postoperative emergence agitation after esophagectomy
Conditions
Interventions
Group A:A bolus dose of dexmedetomidine at 0.4 µg/kg for 15 min before the induction of anesthesia then continued infusion at 0.1 µg/kg/h until 40 min before the end of the surgery
Group B:adminster the saline in the same manner as dextomedetomidine in Group A
Sponsors
TongLing People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Approved by the hospital Ethics Committee and signed informed consent; 2. Patients expected to undergo esophagectomy, aged from 60 to 75 years; 3. American Society of Anaesthesiologists physical status from 1 to 3.
Exclusion criteria
Exclusion criteria: 1. Severe functional heart, lung, brain or kidney disease; 2. A history of severe arrhythmia; 3. A history of severe allergy; 4. Preoperative chemoradiotherapy; 5. Severe malnutrition; 6. Perioperative treatment with steroids and/or NSAIDs in 3 weeks; 7. Patient rejection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative emergence agitation;Postoperative delirium;Perioperative inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactMudan Zhu
TongLing People's Hospital
Outcome results
None listed