Type 2 diabetes mellitus
Conditions
Interventions
Experimental group 1:metformin
Experimental group 2:metformin + aspirin
Control:Placebo
Sponsors
Department of Endocrinology, Xinqiao Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Men or women aged 30 and 75 years; 2. Type 2 diabetic patients with hyperglucagonemia. Ideally, newly diagnosied type 2 diabetic patients be recruited, this will rule out the confounding factors by other treatments given to the patients; 3. oral hypoglycemic drugs, the general HbA1c <= 10%, the entire study period does not adjust the amount of antidiabetic drug usage.
Exclusion criteria
Exclusion criteria: 1. poor blood pressure control: SBP> 180mmHg, DBP> 100mmHg; 2. other diseases affecting the metabolism of glycolipid: hyperthyroidism, hypothyroidism, Cushing's syndrome; 3. Heart failure (NYHA classification: III - IV); 4. ALT and / or AST> 3 times the upper limit of normal (ULN), or active liver disease; 5. PLT 135 mmol/L (1.5 mg/dL (male), and 110 mmol/L (1.3 mg/dL) (female); 7. 2 years had malignant tumors; 8. patients with bleeding tendency; recent gastrointestinal bleeding; anticoagulant therapy; 9. have been pregnant or plan to be pregnant in the near future; 10. known to metformin, aspirin drug allergy; 11. 30 days participated in other drug clinical trials; 12. there are other circumstances that can not participate in the intervention of the followers; 13. The investigators considered the subjects to be affected by the outcome of the assessment of the disease or not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood; | — |
Countries
China
Contacts
Public ContactHongting Zhen
Department of Endocrinology, Xinqiao Hospital
Outcome results
None listed