STEMI
Conditions
Interventions
Recombinant HUman Prourokinase:the Coronary Flow
TIrofiban:the Coronary Flow
normal saline:the Coronary Flow
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Male and female aged 18 to 75 years old; 2) symptoms <12 hours, with thrombolytic indications, excluding thrombolytic contraindications ST-segment elevation myocardial infarction patients; 3) willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1) patients who have undergone intravenous thrombolysis in patients with PCI; 2) history of intracranial hemorrhage; 3) ischemic stroke within 3 months; 4) Suspected aortic dissection; 5) active bleeding or bleeding factors (including menstruation); 6) severe head and face damage within 3 months; 7) Severe or not well controlled hypertension (SBP> 180mmHg or DBP> 110mmHg); 8) 3 weeks of severe trauma or major surgery or can not oppress the bleeding; 9) patients with malignant tumors; 10) combined with severe liver and kidney dysfunction; 11) pregnant women, lactating women or women who may be pregnant; 12) known to study drug or contrast agent allergies or contraindications; 13) patients after coronary artery bypass grafting; 14) coronary angiography showed criminal blood flow TIMI3 grade, and no obvious signs of thrombosis; Patients also participate in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cTFC Myocardial perfusion after PCI; | — |
Secondary
| Measure | Time frame |
|---|---|
| MBG Myocardial perfusion after PCI;Postoperative 2 hours ECG ST segment fall range;CTnT and CK-MB peaks;LVEF and serum NT-proBNP levels were measured at 1 day and 30 days after operation;Thirty - day postoperative myocardial infarction was used to assess infarct size;30 days postoperative major cardiovascular events (MACE) (including death, reinfarction, target vessel revascularization); | — |
Countries
China
Contacts
Public ContactDong Huang
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed