thyroid associated ophthalmopathy
Conditions
Interventions
I:Cyclophosphamide+methylprednisolone
II:Methylprednisolone
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Aged 20 to 60 Years male and female; 2) Euthyroid for at least 3 months; 3) Moderate to severe and active thyroid associated ophthalmopathy; 4) Not been treated for their orbitopathy except for local measures; 5) Not been treated with radioioding or thyroidextomy; 6) Gave their informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1) History of HIV, hepatitis C or hepatitis B Positive, and chronic recurrent or active infection; 2) History of peptic ulcer within 3 months; 3) History of malignant tumor; 4) Uncontrolled diabetes mellitus; 5) Chronic obstructive pulmonary disease, or asthma treated with oral glucocorticoids; 6) Patients with a history of chronic liver disease or liver disorders, ALT or AST above 2.5 times upper limit of normal; 7) Uncontrolled hypertension; 8) Cardiovascular or cerebrovascular disease clinically significant; 9) Combined with ophthalmological signs caused by other diseases; 10) Underhone ophthalmic aurgery within 3 months; 11) Use of corticosteroids and other immunosuppressive agents during 12 weeks before to inclusion period, or with systematic diseases treated with corticosteroids and other immunosuppressive agents; 12) Pregnant patient or patient who is planning to become pregnant during the study; 13) Allergic to cyclophosphamide or methylprednisolone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response;hemorrhagic cystitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Deterioration;GO-QoL;NOSPECS;CAS;proptosis;lid width;diplopia;IOP;??; | — |
Countries
China
Contacts
Public ContactJin-Wei Cheng
Shanghai Changzheng Hospital
Outcome results
None listed