Disease expected to undergo video-assisted thoracoscopic surgery for lung lobectomy
Conditions
Interventions
DEX (Dexmedetomidine) group:Dexmedetomidine
Control group:physiologic saline
Sponsors
Shanghai Pulmonary Hospital affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients expected to undergo video-assisted thoracoscopic surgery for lung lobectomy; (2) American Society of Anaesthesiologists physical status from 1 to 3; (3) Aged from 18 to 75 years; (4) Perfect admission examination; (5) Approved by the hospital Ethics Committee and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) heart failure (New York Heart Association class > II); (2) a history of arrhythmia or treatment with antiarrhythmic drugs; (3) bradycardia [heart rate (HR) 30 kgm-2); (7) restrictive lung disease and/or Forced expiratory volume in 1s percent predicted(FEV1%=40%); (8) Patients participating in other clinical trials ; (9) For other reasons, investigators did not consider it appropriate to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index(OI); | — |
Secondary
| Measure | Time frame |
|---|---|
| interleukin-6(IL-6);interleukin-10(IL-10);Tumor Necrosis Factor-a(TNF-a);heart rate, HR;mean arterial pressure (MAP);end-tidal carbon dioxide concentration (ETCO2);Peak airway pressure;Pplat;Postoperative pulmonary complications;arterial blood PH;BIS;Postoperative sedation score;Postoperative analgesia score; | — |
Countries
China
Contacts
Public ContactLv Xin
Shanghai Pulmonary Hospital affiliated to Tongji University
Outcome results
None listed