Postoperative cognitve dysfunction
Conditions
Interventions
1:sevoflurane only
2:sevoflurane plus propofol
3:sevoflurane plus dexmedetomidine
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients had to between 18 and 80 years of age and ASA physical health class I to III, who were receiving laparoscopic surgery.The operation time must between 2 to 6 hours. The patients or their clients must understand the study and sign their names on the document
Exclusion criteria
Exclusion criteria: (1) cognitive impairment as evidenced by a Mini Mental State Examination score below 24 (of 30 possible points) from the screening test of overall cognitive status at patients' initial visit; (2) history of alcoholism, drug dependence, psychiatric, or neurological diseases, e.g., Alzheimer disease, stroke, and psychosis; (3) severe visual or auditory disorder; (4) unwillingness to comply with the protocol or procedures; (5)inability to understand the language (Mandarin Chinese) used; and/or (6) terminal status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POCD;serum inflammatory factors; | — |
Countries
China
Contacts
Public ContactJianhui Liu
Shanghai Tongji Hospital, Tongji University
Outcome results
None listed